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CBDV – Cannabidivarin also known as Cannabidivarol

Cannabidivarin (CBDV) is a non-psychoactive cannabinoid found in Cannabis and Hemp that may have therapeutic efficacy in the resolution of pain, mood disorders, and inflammatory diseases. CBDV is also not very abundant, which can make the compound difficult to come by.

Cannabidivarin is being actively developed by GW Pharmaceuticals as the experimental compound GWP42006 as it may have “the ability to treat seizures in pre-clinical models of epilepsy with significantly fewer side effects than currently approved anti-epileptic drugs.” They will continue to study its use in epilepsy, however, they are expanding their investigations to include its potential use in Autism Spectrum Disorder, Rett syndrome and Fragile X among others.

CBG – Cannabigerol

CBG may act on very specific physiological systems and problems, and results for medicinal use are promising:

• May be more potent than CBD as a sleep aid.
• Endocannabinoid receptors are prevalent in eye structures.  Interestingly, CBG may be particularly effective in helping glaucoma because it reduces intraocular pressure. It may also be a powerful vasodilator and have neuroprotective effects to boot.
• In animal experiments involving mice, it was found that CBG may be effective in decreasing the inflammation characteristic of inflammatory bowel disease.
• In a recent 2015 study, it was found that CBG may protect neurons in mice with Huntington’s disease, which is characterized by nerve cell degeneration in the brain.
• CBG is showing great promise as it may be a powerful cancer fighter. Specifically, it was found that CBG may block receptors that cause cancer cell growth. In one such study, it inhibited the growth of colorectal cancer cells in mice, thereby slowing colon cancer growth. CBG inhibited tumors and chemically-induced colon carcinogenesis, therefore demonstrating a very exciting possibility for a cure for colorectal cancer.
• European research shows evidence that CBG may be an effective antibacterial agent, particularly against methicillin-resistant Staphylococcus aureus (MRSA) microbial strains resistant to several classes of drugs.
• In a very recent 2017 study, researchers found that a form of CBG purified to remove delta-9 THC may be an effective appetite stimulant in rats. This may lead to a novel non-psychotropic therapeutic option for cachexia, the muscle wasting and severe weight loss seen in late stage cancer and other diseases.
• In a study that looked at the effects of five different cannabinoids on bladder contractions, CBG tested best at inhibiting muscle contractions, so it may be a future tool in preventing bladder dysfunction disorders.