CBD Oil benefits are new to many people but the benefits for balancing the body and helping to maintain Homeostasis is far reaching and was discovered back in the early nineties. In 1992 Dr. Raphael Mechoulam who discovered the Endo-Cannabinoid System within the human body. The ECS is a system within the human body that controls millions of chemical modulations including influence to the Immune System. Check out some of educational videos below to learn more. 

We do not sell any Cannabis products – 100% THC FREE


Conditions That CBD Helps


Attention Deficit (Hyperactivity) Disorders are extremely common, affecting between 6% and 11% of U.S. children in America. The most common medical treatments for anxiety in the U.S. are the use of pharmaceutical drugs like stimulants (amphetamines), anti-hypertensive drugs, and cognition enhancing medications. However, it’s important to realize that these pharmaceutical drugs often have unwanted side effects. In addition to self-care and therapy, you can incorporate CBD into your regimen for natural, plant-based adjustment to the Serotonin receptors to bring on a calming effect.


Because of its influence to the ECS, CBD oil may lessen the visible signs of aging skin by counteracting free-radical damage, Our CBD Topicals are 100% natural with no phosphates, sulfates, emulsifiers or stabilizers so they may help visibly diminish issues like wrinkles and dry skin.


CBD is a cannabinoid that occurs naturally in the HEMP plant. Our body consists of millions of receptors which can be found throughout the central and peripheral nervous system. CBD is a cannabinoid which binds to these special receptors in our body when we consume it. In essence, CBD may help to reduce the pain and swelling associated with IBS and Crohn’s disease.


While it is still being studied, Cannabinoids seem to have influence on hypothyroidism and hyperthyroidism due to the changes they make by activating TRPV-1 Receptor which is known to mediate pain, inflammation and body temperature through specific influence to the Vagus nerve.


Opioid addiction is a horrible. It may start innocently with the use of prescription opioids for post-operative pain. They’ll deliver pain relief with a euphoric high by flooding the brain with opioid chemicals that overwhelm receptors. The brain’s natural response is to restore balance by weakening the effect that these chemicals have on the brain. Over time, to achieve pain relief and restore that euphoric high, more pills must be popped, more morphine dripped. Eventually, the drugs themselves are insufficient and harder drugs like heroin are sought.

CBD’s influence to regulate opioid reward stems from its ability to enhance serotonin signaling in the brain through the 5 HT1A receptor. Serotonin is a mood-regulating neurotransmitter that is a common target of anxiety and anti-depressant medications. CBD’s anxiety-adjusting effects can be utilized in addiction treatment by relieving this prominent withdrawal symptom.  If you or a loved one suffers from opioid addiction, stop into our CBD dispensary in Phoenix, or any of our other locations, and we’d be happy to discuss possible solutions with you.


Initial research Initial research published in the Journal of Alzheimer’s Disease found that Cannabidiol was able to adjust the development of social recognition deficit in participants. This means that CBD could help people in the early stages of Alzheimer’s. Additionally, we know that Cannabidiol helps to detoxify the brain by removing beta amyloid plaques which has been shown to be present in many Alzheimer’s patients. Further, the detoxifying benefits of Cannabinoids help to seal up a leaky blood brain barrier which when overlooked can allow urea to seep into the blood stream and get into the neurological field contributing to different forms of dementia.


CBD’s direct influence to the Serotonin receptor augments serotonin signaling and lowers Cortisol in the brain through the 5 HT1A receptor. Serotonin is a mood-regulating neurotransmitter that brings on a state of calm. The reduction of Cortisol ( a stress molecule ) also helps bring on this calming effect.


Migraine attacks normally involve a severe, recurrent throbbing pain on one or both sides of the head, which can last anywhere between 4 and 72 hours. These attacks may be accompanied by other disabling symptoms, including dizziness, nausea, vomiting, light sensitivity, and tingling or numbness of the face or extremities. Migraines are caused by many unique factors in each person’s body. Just a change in diet such as the avoidance of cheese, dairy and red meat has shown to help reduce Migraines in people.

Numerous studies have also shown that CBD can adjust inflammation in the Neurological field which helps to lower the occurrences of Migraines. If you’d like more information on CBD benefits, stop into our CBD dispensary in Phoenix, or any of our other locations, and we’d be happy to discuss them with you.


CBD’s direct influence on the Serotonin receptor in the brain augments serotonin signaling and lowers Cortisol in the brain through the 5 HT1A receptor. Serotonin is a mood-regulating neurotransmitter that brings on a calming state. The reduction of Cortisol (a stress molecule – too much causes extreme stress) also helps bring on this calming and balancing effect.


CBD has the ability to minimize anxiety through its influence to the 5 HT1A Hydroxytryptamine receptor, which can be helpful in improving restful sleep.

We now offer CBG (Cannabigerol). People report that 5mg of CBG matches 40mg of CBD for sleep.  You can learn more about CBG HERE.

See our video on Sleep and how sleep cycles are affected by EMFG stress, and mobile devices.


Cannabinoids, such as CBD, attach themselves to millions of receptors in our brain and immune system.  One of these receptors, called a CB2 receptor, plays a key role in the immune system. CBD has been shown to upregulate Glutathione as well as augment Anandamide in the brain (the Bliss Molecule) to help reduce the feelings associate with the discomfort of pain.


Due to the importance of the cardiovascular system, it’s quite obvious that any malfunctioning or illnesses involving this system could have catastrophic consequences. It just so happens that diseases of the cardiovascular system are among the leading causes of death worldwide. Conditions within this category include chronic rheumatic heart diseases, hypertension, coronary heart disease, stroke, and diseases of the arteries, arterioles, and capillaries.

Evidence suggests that CBD is beneficial to the cardiovascular system, with many studies pointing towards the cannabinoid’s anti-inflammatory and antioxidant effects as the key to its therapeutic action.


The FDA has already approved one CBD based drug specifically for use on people with Multiple Sclerosis opening the door to other research in the field of neurological health. MS is a neurological condition that effects the immune system and over time eats away at the protective covering of nerves.


All mammals have what’s called an ECS or Endo Cannabinoid System which governs millions of modulatory responses in the body and brain. It controls resting heart rate, respiration, digestion, even sleep. Cannabinoids, such as CBD, stimulate Glutamate and this helps to govern how inflammation is caused and controlled throughout the body. Obviously, we know that a plant-based diet will reduce inflammation especially the avoidance of red meat, cheese and dairy which have been proven to be all high in processed chemicals. See our video on Cheese.


Hemp extracts and CBD oil has been found to soothe sensitive skin, and studies indicate that it may even be able to help inhibit certain triggers of disorders like psoriasis and improve eczema-prone skin. Again, far more research is needed, but what exists certainly looks promising, and researchers speculate it all comes down to CBD’s influence to the Endo-Cannabinoid system along with its natural anti-fungal properties.


The Endocannabinoid system is a fully functioning regulator for our mood, appetite, temperature etc. The main cannabinoid receptors located throughout the body are called CB1 and CB2. Naturally pure organic CBD extracts bonded to these receptors and help the brain in producing more dopamine which is known to inhibit the symptoms of Parkinson’s. Additionally, we know that Cannabidiol helps to detoxify the brain by removing beta amyloid plaques and Peroxyacyl Nitrates which has been shown to be present in Parkinson’s patients. Further, the detoxifying benefits of Cannabinoids help to seal up a leaky blood brain barrier. A leaky BBB can allow urea (chemical compound in Urine) to seep into the blood stream and get into the neurological field contributing to different forms of dementia.


Depression is caused by many different factors. For many it is a chemical imbalance in the brain. The cannabinoids produced in our bodies (endocannabinoids) help to regulate several functions of the body such as mood, pain sensation, sleep, and appetite. When we ingest phyto-Cannabinoids, we get he same result, a balance of brain chemistry to bring on a state of calm.


Acne treatment is another promising use for CBD. The condition is caused, in part by overworked sebaceous glands in the body. Meaning they are out of balance. A 2014 study published by the Journal of Clinical Investigation found that CBD helps to lower the production of sebum that leads to acne.


CBD may help to promote bone mass by blocking the GPR55 ( G Protein Coupled Receptor ) signaling. This gene is responsible for “Bone Reabsorption” which is what happens when calcium and minerals are released from bones into the blood stream “weakening” the bones. This is referred to as “oxidative stress” as we age. Cannabinoids have shown in lab mice to have a modulatory effect on oxidative stress.


The FDA has already approved one CBD based drug specifically for use on people with Multiple Sclerosis opening the door to other research in the field of neurological health. MS is a neurological condition that effects the immune system and over time eats away at the protective covering of nerves.


Hemp derived CBD (cannabidiol) works differently than the THC that dominates most cannabis strains. It does not bind to CB1 and CB2 receptors as THC does. Rather, CBD supports runs interference on the mechanics that launch nausea and vomiting through the Vagus Nerve.

  • CBD triggers 5-hydroxytryptamine-1A (5-HT1A) that reduces the sensation of nausea.
  • CBD influences and modulates the flow of serotonin to reduce further stimulation of the vomiting center in the brain.
  • CBD augments anandamide, a natural enzyme and neurotransmitter that produces a heightened state of happiness, so they call it “the bliss molecule.”

Type 1 diabetes results from inflammation that occurs when the immune system attacks cells in the pancreas. Because of the influence to the Vagus Nerve, CBD can have a modulatory balance to the way we digest our food and process sugars. Research published in 2016 by Clinical Hemorheology and Microcirculation found that CBD may ease this inflammation in the pancreas. This may be the first step in finding a CBD-based treatment for type 1 diabetes.


CBD’s direct influence to the powerful Serotonin receptor in the brain helps to balance moods by augmentation to the serotonin signaling and lowers Cortisol in the brain through the 5 HT1A receptor. Serotonin is a mood-regulating neurotransmitter that brings on a state of calm. The reduction of Cortisol (the bodies fight/flight stress molecule ) also helps bring on this calming effect.


We have many people stopping in on a daily basis to our CBD dispensary in Phoenix, and our other locations due to discomfort from arthritis.  Arthritis is the leading cause of disability in the United States, affecting over 50 million Americans. The two most common types of arthritis are:

  • Rheumatoid arthritis (RA): An autoimmune disease in which a person’s immune system attacks their joints, causing inflammation. RA commonly affects the hands and feet and leads to painful, swollen, and stiff joints.
  • Osteoarthritis (OA): A degenerative disease that affects joint cartilage and bones, causing pain and stiffness. It often affects the hip, knee, and thumb joints.

When we eat wrong, we get acid build up and inflammation. When we eat right with lots of plant based nutrients, including phyto cannabinoids, we reduce inflammation which lowers to occurrence of this condition.


CBD may protect against amphetamines’ ability to induce long-term changes in dopamine signaling.  This is the brain chemical involved in reward processing that underlies early stages of addiction. Nicotine changes the way your genes function and not for the better. Many people are using CBD in inhalation form to reduce their need to inhale toxic carcinogens found in many cigarettes.

Have Questions About CBD?


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CBD Near Me

Very Thankful

One of my specialist doctors recommended I try CBD from azWHOLEistic, as I have been experiencing arthritis-like autoimmune pain and swelling for 6 months. Most likely caused by extreme stress and anxiety in the beginning of 2021. Nothing shows up in blood tests except for high generalized inflammatory markers. Jenny at the Sun City location helped me make the choice of CBG as an alternative medicine to try to decrease the inflammation. After only 2 weeks, it worked! My latest bloodwork showed that my inflammatory markers, while still a little high, decreased by more than 50%. My pain and discomfort is also significantly decreased and I feel I am also handling my stress much better. I'm very thankful to have tried this!!

Gila620 / Sun City, AZ
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TRU Infusion CBD and Pain Lotion

I have been using both products for over 6 months now and am always satisfied with the results.  The pain lotion I use for my arthritic hands and the MCT Oil Tincture for the pain in my back.  Both really do the job.  The price and availability are great too.

Bruce / Scottsdale, AZ
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CBD For Crohns

I have been coming here for 4/5 months now for my hemp products to help with my Crohn’s and general pain. The product I’ve been using has been a lifesaver for me, especially when working 45-50hrs a week and having a weaker immune system. Jenny and Esteban are amazing and I will keep coming back.

Marissa W / Sun City, AZ
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Jeff Is Very Knowledgeable

Jeff has been very helpful my entire timeline in visiting the Tempe CBD Dispensary. He offered great advice upon my travel excursions, applied a discount and described the vape device extremely well in my opinion. He also is very knowledgeable about CBD. I will be shopping here from now forward. Thank you Jeff!!

Colleen K / Tempe, AZ
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CBD For Ostearthritis - Great Suggestion From Jenny!

I was desperate to find a CBD dispensary that was open after 6:30 on a Friday. I found azWHOLEistic from google and made it here ten minutes before closing, and thank God for Jenny!  Her knowledge was such that I was able to quickly narrow down exactly what I needed for my osteoarthritis and sleep issues. The customer service was the perfect blend of personal and professional that I now have no desire to search for another Cbd dispensary. This one will be my go to. Thank you so much. I am grateful to have found your store. 🙂

Lilac P / Phoenix, AZ
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Fantastic Results

I use the CBD oil on a sciatic problem and the results have been fantastic. In less than 2 weeks I could sleep through the night for the first time in years. I also recommend the pain slave for any aches and pains you may have. Once again these products will generally exceed your expectations. The staff is very knowledgable as well, which is so helpful. Great products, great people!

Larry / Phoenix, AZ
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Great Product and Service

I spent hours online checking out for the best quality and the most knowledgeable. This place is it , great product and great service

Bob B / Phoenix, AZ
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XTRU Infusion CBD and Plant Health Therapeutic Pain Lotion

I have been using both products for two months now and have continued success eliminating pain in my hands and body.  Both are so easy to use and almost instant relief.  With Infusion I take it morning and night so keep it working 24 hrs a day, continuously relieving body pain an contributing to a restful nights sleep.

Bruce / Scottsdale, AZ
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Wonderful Company and Product

I can't say enough about AZ Wholeistic.  The company is top notch from their customer service, to their willingness and ability to educate us all about CBD to their excellent products.  I know that I can trust their products and in the CBD marketplace, that is 100% necessary these days.  I have been using their CBD, primarily for peaceful sleep for several years and I will continue to do so.

Nancy / Lopez Island. WA
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This place is great! Super helpful and knowledgeable staff with high quality CBD products. Be sure to ask for Jenny, she is awesome!

Chris D / Phoenix, AZ
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Dolce Vida

Jeff at Tempe is an amazing individual who like everyone at Az Wholeistic truly cares about you.....not just pushing a product. I've been a customer for almost 2 years and won't go anywhere else. I've been having some extra challenges lately and switched from my normal and tried the Dolce Vida........Amazing! Wonderful sleep, clear mind during the day, and great attitude. You have to try this stuff! Thanks Jeff for all you do for us!

John / Tempe, AZ
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CBD For Spinal Stenosis

I have been here twice for my 1500 mg cbd lotion. All I can say is WOW! I have spinal stenosis and there are days that I just cannot even get out of bed. But with this cbd it relieves my pain within 20 minutes or so. Thank you Jenny amd Jason for being so helpful. I recommend this to anyone in pain. I also recently tried it on my headaches and worked beautifully.

Sue G / Tempe, AZ
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Great Service

Jason is great, and so far the results from taking CBD have been impressive! I suffer from chronic pain, and anxiety...CBD has helped a lot with that! My wife was skeptical but started trying it too; we have seen a dramatic decrease in her migraine occurrences, as well as intensity. Her sleep has improved, and her anxiety was seriously reduced!

David L / Tempe, AZ
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Best Customer Service

This is by far the best CBD dispensary in the Valley. As an industry professional (on the marijuana side) I truly appreciate the knowledge and care with which azWHOLEistic treats everyone who walks in the door. If you are in the market for CBD products or if you want to see what CBD can do for you or someone you love, stop by and let Jeff (even though he spells his name provide you with the best customer service and expertise in the market. azWHOLEistic is the only CBD dispensary I trust for quality products and information.

Geoff G / Tempe, AZ
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Sleeping Deeply

I came into the store thinking I would just try the pain lotion and go home and see how it worked.  I applied the lotion and talked with the very knowledgable sales person there.  In a matter of minutes, the pain in my hands had gone away.  I find I hardly need to reapply the lotion and now am taking the oral MCT oil tincture daily and pain in body is gone and sleeping really deeply.

Bruce / Phoenix, AZ
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CBD For Dogs

We don't say it lightly that AzWHOLEistic and the cbd oil we now purchase have been the tools God has used to allow us to see a real life miracle! 6 weeks ago, we made the heart breaking decision to put our 14 1/2 year old dog down. While otherwise extremely healthy, we found out he had a growth on his spine that was pressing on a nerve and not allowing his muscle to fire so much so that his back leg atrophied almost completely in about a week. We could only conclude he was in extreme pain. We started him on cbd oil as a means to make him as comfortable as possible while we arranged for in-home euthanasia. When my husband went into azWHOLEistic, he was in tears. The staff took time to genuinely help us by asking questions, explaining our options, giving thorough instructions and encouraging him. It was far greater service than we've ever received from a vet. We've since been back and have received the same extraordinary care. They know what they're talking about and are so kind. We weren't expecting this, but our dog has made pretty significant improvements! He takes short walks whenbefore, he could barely stand. He is so much like his old self that we can tell he is not suffering like he was, which is all we want for him. He is still with us and was able to see another Thanksgiving, another half-birthday, and find out he is going to be a big brother! We are taking it one day at a time, but we know we have been given the gift of time with him and we are so grateful for each day. We don't even want to think about what it would look like if we hadn't gone into azWHOLEistic when we did. Thank you azWHOLEistic for the products, the cars, and the life change you've given us. We are so grateful!

Veronica S / Phoenix, AZ
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CBD For Arthritis Pain

Hi, I am writing to say thank you to Jason. My 94 year old mom who lives just up the road from you at The Gardens of Sun City came in about two weeks ago. She was skeptical about CBDs but has very bad arthritis pain. Jason was very helpful in helping her select a tincture that would be appropriate for her- 750mg oil. It has proved to be a game changer!! I just came back to Durango CO, where I live after visiting her in Sun City, and was so impressed with her progress while I was there. I stopped by the store and talked with Ms. Breckenridge, who was also very knowledgable, but wanted to say thank you to Jason personally. My mom is in a wheelchair, slight little Italian woman with short white hair (I know that describes most women in that area!) who came in with her assisted-living van driver.
Again- thank you Jason! It was so good to see her pain at bay.

Dusty M / Durango, CO
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CBD For Spinal Stenosis

CBD For Spinal Stenosis

First time CBD user here. Had the good fortune of selecting Sun City CBD and Jenny. They allowed an actual pain reduction test right there in the store. It actually reduced my back pain (Spinal Stenosis diagnosis by the doctor) by about about 80%.

Jeff S / Sun City AZ
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Freida - CBD For Sleep

CBD For Neck Pain

Very knowledgeable group. Went through a couple bottles of CBD Oils then Chris made a suggestion that maybe I should try the straight CBD Crystal form. So glad that I did. First time for me to sleep through the night due to my nerve pain in neck. I believe in this that I went back and bought two more jars from Jason and he explained to me on how to adjust my dosage. I also use the REM for sleep. My ultimate goal is to be able to stop using tylenol and benadryl.

Freida H / Phoenix, AZ
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