CBG – Cannabigerol
CBG is a single molecule – like CBD which many people are already aware of… found in the Cannabis and the HEMP plant. All our products are extracted from Hemp per the Hemp Farm Bill. This molecule has influence over a vast array of receptors throughout the body and brain through the Endo-Cannabinoid System.
As with all cannabinoids…these receptors modulate many physiological conditions like pain, gastrointestinal conditions including IBS. Cannabinoid receptors are also highly concentrated in the structures of the eye. CBG has shown effectiveness at reducing intraocular eye pressure associated with conditions like Glaucoma and Retinopathy.
It’s natural anti-inflammatory benefits ( TRPV-1 receptor ) combined with influence to the serotonin receptor – (5-HT1a receptor) makes CBG appropriate for anxiety and the reduction of cortisol in the brain.
To summarize CBG works as well as CBD, perhaps better on pain, but with the added benefits of Gastro-intestinal and vision conditions.
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CBG and The Endocannabinoid System
The human body’s built-in endocannabinoid system (eCS) works to keep the body in its balanced state of homeostasis. While there are specific details about how cannabinoids work, in general the endocannabinoid system performs different functions specific to each area of the body. For example, at an injury site, the eCS can help regulate immune cells to limit inflammation. New studies indicate CBG may help with pain as much or more than CBD.
Promising Uses For CBG
CBG has been found to act on very specific physiological systems and results for medicinal use are promising:
- Endocannabinoid receptors are prevalent in eye structures, and interestingly, CBG is thought to be effective in helping glaucoma because it reduces intraocular pressure.
- In animal experiments involving mice, CBG was found to be effective in decreasing the inflammation characteristic of inflammatory bowel disease.
- In a recent 2015 study, CBG was shown to protect neurons in mice with Huntington’s disease, which is characterized by nerve cell degeneration in the brain.
- European research shows evidence that CBG is an effective antibacterial agent, particularly against methicillin-resistant Staphylococcus aureus (MRSA) microbial strains resistant to several classes of drugs.
- In a very recent 2017 study, researchers showed that a form of CBG purified to remove delta-9 THC was a very effective appetite stimulant in rats. This may lead to a novel non-psychotropic therapeutic option for cachexia, the muscle wasting and severe weight loss seen in late stage cancer and other diseases.
CBG has been referred to as the mother of all cannabinoids. Early in the cannabis flowering cycle, cannabigerolic acid (CBGA) is converted by enzymes to cannabinoids including THC, CBD, CBG, cannabinol (CBN), and cannabichromene (CBC). Because CBGA is quickly converted to THC or CBD as the plant matures, only small amounts of CBG are found in the Cannabis sativa plant. The low concentration of CBG in the plant has made studying the compound challenging. However, in hemp and species with low THC concentration, the concentration of CBG can be much higher. Furthermore, genetic modification has resulted in some strains being developed that are almost all CBG and CBGA.
CBG is a relatively weak partial agonist of the cannabinoid receptors CB1 and CB2, with its effects at CB2 thought to play a role in inhibiting the intoxicating effects of THC. CBG also increases the body’s endogenous anandamide, which is involved in pain, depression, appetite, memory, and fertility.
CBG has been found to interact with a number of receptors implicated in pain, inflammation, and heat sensitization including transient receptor potential (TRP) channels. CBG stimulates TRPV1, TRPV2, TRPV3, TRPV4, and TRPA1 receptors and antagonizes TRPM8 receptors.
CBG Research Continues
Scientists are excited about these initial CBG results and are promoting future research with CBG alone or CBG in combination with other cannabinoids and therapies for the treatment of multiple maladies. Because it is non-psychotropic, CBG has a promising wide range of potential applications not only for the problems mentioned above, but also as an analgesic, therapy for psoriasis, and as an antidepressant.
READ MORE IN DEPTH STUDY
Where To Buy CBG In Phoenix
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The CBG Extraction Process
Have you ever drunk grain alcohol? If so, you were drinking ethanol. Ethanol is “a colorless volatile flammable liquid C 2 H 5 OH that is the intoxicating agent in liquors and is also used as a solvent and in fuel—called also ethyl alcohol, grain alcohol,” according to Merriam-Webster. It “can be fermented from many sources of starch, including corn, wheat, grain sorghum, barley, and potatoes, and from sugar crops such as sugar cane and sweet sorghum. Because there has been an abundant supply of corn, most of the ethanol made in the United States is from corn,” the University of Illinois Extension explains.
Ethanol and Its Guidelines
The Food and Drug Administration (FDA) classifies ethanol as a Class 3 solvent with low risk for acute or chronic toxicity in pharmaceutical manufacturing processes where the residual is less than 5,000 ppm or 0.5 percent. The FDA also implies that residual solvents in this category should be limited to 0.5 percent through rigorous quality assurance and quality control programs. Despite those FDA guidelines, some states have adopted more conservative safety limits suggested by the Occupational Safety and Health Administration (OSHA) and the National Institute for Occupational Safety and Health (NIOSH). OSHA and NIOSH set the worker environmental exposure limit for ethanol at 1,000 ppm of Total Weighted Average (TWA) over an eight-hour work shift, which means that some states are allowing only 0.1 percent residual ethanol in extracted products.
Ethanol extraction is a single-stream process that can be conducted under warm or cold conditions. An example of a warm ethanol extraction processes is the Soxhlet technique. This technique essentially boils ethanol in a flask or pot, then condenses the alcohol on a cooled-coil, which then drips through the packed flower material, stripping the cannabinoids and terpenes during the process. The advantage to this approach is that the extraction is time efficient and of relatively low solvent-to-feed ratio.
However, the warm-ethanol technique is generally a small-batch approach that extracts chlorophyll/waxes and decarboxylates the cannabinoids due to the heat involved. (Decarboxylation is the conversion of THCA, for example, to THC through heating and agitation that yields carbon dioxide during the process.) Therefore, heated ethanol extractions might require additional dewaxing and clarification steps. This type of technique is also limited in the number of products it can produce because all the acid-form cannabinoids are decarboxylated during the extraction. While heating ethanol can increase the extraction process’s efficiency, ethanol is a good solvent for extracting terpenes and cannabinoids. Therefore, it can be used as an extraction solvent at room temperature or under supercooled conditions. Using ethanol at room temperature or under cooled conditions are the most common practices because these conditions allow for the retention of cannabinoid acid forms that can be leveraged to manufacture shatters, THCA crystals or THCA-rich oral formulations.