CBC – Cannabichromene

CBC Cannabichromene – Although first discovered in 1966, CBC research, like research on many other cannabinoids, has been held back by federal restrictions. Recently since 2020, the research has been ramping up significantly and has shown the medical potential many cannabinoids have.

Modern breeding practices have focused on CBD and THC, so CBC concentrations have fallen, but CBC has always been one of the Big Six cannabinoids. Like THC and CBD, CBCa is formed from CBGa. CBCa then decarboxylates into CBC. It is mostly found in low concentrations in modern strains of Cannabis and HEMP.


What We Know About CBC

Despite being one of the most prominent cannabinoids in cannabis, CBC does not get the attention that it deserves. As a non-psychoactive compound, it offers several of the benefits that THC does while not having such pronounced mental effects.

Research has shown that CBC does not interact significantly with CB1 receptors in the body, but that it does have some interactions with the CB2 receptors ( more immune system ). It also interacts with TRPV1 and TRPA1 receptors, both of which are linked to pain, meaning that it can relieve pain with minimal to no psychoactive impact.

Potential Uses for CBC Include:


  • Research as far back as 1981 has found that CBC is especially useful in fighting bacteria. It has substantial effects on a variety of bacteria, including acid-fast strains. It has moderate effects as an anti-fungal as well as an anti-viral. 

Anti-Inflammatory and Anti-Pain

  • In the current decade, pain is one of the most common reasons people use prescribed substances. CBC appears to be an effective agent at reducing inflammation without directly interacting with cannabinoid receptors. Although some suggest its ability to reduce inflammation is stronger with the presence of other cannabinoids like CBD and CBG. It can reduce swelling and inflammation in the digestive tract. CBC targets pain at the spinal level, and although not as effective at THC at relieving pain, it does so without psychoactive effects. 


  • Millions of people worldwide suffer from stress and anxiety due to disorders and traumas. When used with other cannabinoids, the research found CBC contributes to even superior mood-elevating effects while activating different pathways in the brain than THC. 

Cell Growth

  • A 2013 study on mice found that CBC may promote new cell growth. It has also been found to promote the growth of brain cells and to fight migraines. CBC helps the production of astroglial cells, which fight against conditions such as Alzheimer’s disease and dementia.


  • A 2006 Study found CBC to be the second most effective cannabinoid at preventing tumor growth. One day CBC could be a powerful chemopreventative agent. It is also shown to inhibit the absorption of anandamide, which is linked to a reduction in a variety of cancers.


  • One of the most rampant insecurities people suffer from are caused by common acne. CBC has been found not only to reduce the production of sebum, which is necessary for acne to form, but also to lessen the effects of arachidonic acid. These combined effects prove that CBC could be a potent tool in preventing and managing acne in the future. 

Where To Buy CBC In Phoenix

azWHOLEistic offers high quality CBC in Phoenix at our 4 locations, and our online store.  Click the button below to view:


The CBC Extraction Process

Ethanol Extraction

Have you ever drunk grain alcohol? If so, you were drinking ethanol. Ethanol is “a colorless volatile flammable liquid C 2 H 5 OH that is the intoxicating agent in liquors and is also used as a solvent and in fuel—called also ethyl alcohol, grain alcohol,” according to Merriam-Webster.

It “can be fermented from many sources of starch, including corn, wheat, grain sorghum, barley, and potatoes, and from sugar crops such as sugar cane and sweet sorghum. Because there has been an abundant supply of corn, most of the ethanol made in the United States is from corn,” the University of Illinois Extension explains.

Ethanol and Its Guidelines

The Food and Drug Administration (FDA) classifies ethanol as a Class 3 solvent with low risk for acute or chronic toxicity in pharmaceutical manufacturing processes where the residual is less than 5,000 ppm or 0.5 percent. The FDA also implies that residual solvents in this category should be limited to 0.5 percent through rigorous quality assurance and quality control programs.

Despite those FDA guidelines, some states have adopted more conservative safety limits suggested by the Occupational Safety and Health Administration (OSHA) and the National Institute for Occupational Safety and Health (NIOSH). OSHA and NIOSH set the worker environmental exposure limit for ethanol at 1,000 ppm of Total Weighted Average (TWA) over an eight-hour work shift, which means that some states are allowing only 0.1 percent residual ethanol in extracted products.

The Process

Ethanol extraction is a single-stream process that can be conducted under warm or cold conditions. An example of a warm ethanol extraction processes is the Soxhlet technique. This technique essentially boils ethanol in a flask or pot, then condenses the alcohol on a cooled-coil, which then drips through the packed flower material, stripping the cannabinoids and terpenes during the process. The advantage to this approach is that the extraction is time efficient and of relatively low solvent-to-feed ratio.

However, the warm-ethanol technique is generally a small-batch approach that extracts chlorophyll/waxes and decarboxylates the cannabinoids due to the heat involved. (Decarboxylation is the conversion of THCA, for example, to THC through heating and agitation that yields carbon dioxide during the process.) Therefore, heated ethanol extractions might require additional dewaxing and clarification steps. This type of technique is also limited in the number of products it can produce because all the acid-form cannabinoids are decarboxylated during the extraction.

While heating ethanol can increase the extraction process’s efficiency, ethanol is a good solvent for extracting terpenes and cannabinoids. Therefore, it can be used as an extraction solvent at room temperature or under supercooled conditions. Using ethanol at room temperature or under cooled conditions are the most common practices because these conditions allow for the retention of cannabinoid acid forms that can be leveraged to manufacture shatters, THCA crystals or THCA-rich oral formulations.

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