Our CBD Knowledge Center covers a wide range of information regarding CBD, and Natural Plant Based Phyto-Nutrients.  azWHOLEistic helps educate our clients on proven methods of detoxification and healing. The CBD Knowledge Center is a great starting point for anyone considering the use of CBD or other Phyto-Nutrients.  You will find factual information, from reliable sources that can be trusted.  New information is added on a weekly basis, so be sure to stop in often to keep yourself up-to-date on education, news, legislation, and more!


CBD Knowledge Center

Cannabinoid Education


Did you know that food allergies can be as bad as drug allergies? Food allergies are even more difficult to prevent.

In the video below, we discuss the different blood types, the best foods to eat for you blood type, and how to avoid food allergies. What would you pay to be healthy? Learning to balance your body, mind and spirit will save you thousands in doctors visits, co-pays and prescription medications!

It’s up to you…



Your Blood Type matters when it comes to many things such as Food Sensitivities. New data shows it matters for COVID-19 contraction also.



About Cannabinoids

Cannabidiol – CBD


Found in the leaves and stock of the Hemp plants, CBD or Cannabidiol is the most powerful cannabinoid for modulating homeostasis in the human body. Our immune system makes its own cannabinoids but many of us are deficient and supplementing this compound influences a wide range of chemical processes throughout the body.

All “mammals” may benefit from a regiment of CBD, and at the correct dose, may potentially see relief from many conditions such as the ones listed below.



Many conditions that may potentially respond well to CBD may also respond to CBDA. Though, CBDA is broken down and used by the body differently than its “activated” counterpart. CBDA also may not be as strong as CBD, which is why the dosages of CBDA are typically much higher than CBD. By some arguments, activated CBD is more bioavailable than CBDA.


Cannabichromene – CBC


For a long time, it was thought that the brain stops developing once you reach a certain age. Turns out, this is not the case. Cells responsible for memory and learning, for example, are continuously made via a process called neurogenesis. In folks with dementia and Alzheimer’s, neurogenesis is altered. A study published in 2013 suggests that CBC can encourage neurogenesis.

Cannabigerol – CBG


CBG is a non-psychoactive cannabinoid, meaning it doesn’t produce the “highs” that are synonymous with THC. Because it is present in low levels (usually less than 1%), CBG is considered a minor cannabinoid. Amazingly, however, THC and CBD start out as CBG—it’s the chemical parent of THC and CBD.

Specific enzymes in the plant break CBGA down and “direct” it toward one of the three lines. The acids are exposed to ultraviolet light or heat, and voila, they become the cannabinoids we know: THC and CBD. In most strains, CBGA is immediately converted to either THCA or CBDA. Thus, more THC means less CBG and CBD (and vice versa) by nature of how these compounds are synthesized.

More about CBG HERE

Cannabidinol – CBN


Its name may bear striking resemblance to CBD, but cannabinol, or CBN, offers a unique profile of effects and benefits that have researchers clamoring for more scientific investigation.  CBN’s most pronounced, characterizing attribute is its sedative effect.

Cannabidivarin – CBDV


Early laboratory and rodent research suggests that the cannabinoid may have some therapeutic potential. Though all research thus far is in its early stages and scientists have a long way to go before they make any firm conclusions about the benefits of CBDV.

CBDV is the precursor to another compound of interest, THCV. THCV is currently being studied as a potential treatment for diabetes. Research suggests that CBDV transforms into THCV under acidic conditions.

Thus far, CBDV has shown potential in three major areas of research. Though, studies on the cannabinoid are limited to preclinical investigations in the laboratory. CBDV is also not very abundant, which can make the compound difficult to come by. Still, it may be worthwhile for growers and breeders to experiment with creating chemovars (cultivars that produce specific chemical compounds) that contain higher levels of CBDV.

World Health Organization Report On CBD

World Health Organization CANNABIDIOL (CBD) Pre-Review Report
Agenda Item 5.2 Summary:

Cannabidiol (CBD) is one of the naturally occurring cannabinoids found in cannabis plants. It is a 21-carbon terpenophenolic compound which is formed following decarboxylation from a cannabidiolic acid precursor, although it can also be produced synthetically.  CBD can be converted to tetrahydrocannabinol (THC) under experimental conditions;however, this does not appear to occur to any significant effect in patients undergoing CBD treatment.

In experimental models of abuse liability, CBD appears to have little effect on conditioned place preference or intracranial self-stimulation. In an animal drug discrimination model CBD failed to substitute for THC. In humans, CBD exhibits no effects indicative of any abuse or dependence potential.

CBD has been demonstrated as an effective treatment of epilepsy in several clinical trials, with one pure CBD product (Epidiolex®) currently in Phase III trials. There is also preliminary evidence that CBD may be a useful treatment for a number of other medical conditions.  There is unsanctioned medical use of CBD based products with oils, supplements, gums, and high concentration extracts available online for the treatment of many ailments.

CBD is generally well tolerated with a good safety profile. Reported adverse effects may be as a result of drug-drug interactions between CBD and patients’ existing medications.

Several countries have modified their national controls to accommodate CBD as a medicinal product.

To date, there is no evidence of recreational use of CBD or any public health related problems associated with the use of pure CBD.

So The FDA Says CBD Is Not Safe? Really?! Look Who Owns The Patent

Did You Know?

CBD is patented by The US Department of Health and Human Services

Cannabinoids have been found to have antioxidant properties, unrelated to NMDA receptor antagonism. This new found property makes cannabinoids useful in the treatment and prophylaxis of wide variety of oxidation associated diseases, such as ischemic, age-related, inflammatory and autoimmune diseases. The cannabinoids are found to have particular application as neuroprotectants, for example in limiting neurological damage following ischemic insults, such as stroke and trauma, or in the treatment of neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease and HIV dementia. Nonpsychoactive cannabinoids, such as cannabidoil, are particularly advantageous to use because they avoid toxicity that is encountered with psychoactive cannabinoids at high doses useful in the method of the present invention. A particular disclosed class of cannabinoids useful as neuroprotective antioxidants is formula (I) wherein the R group is independently selected from the group consisting of H, CH3, and COCH3.
What Is The Endo Cannabinoid System?

Surgeon Dr. David Allen talks about how CBD heals the body.

Full CBD Lecture Video Series With John Callahan
Understanding CBD Video Series
Biology of CBD and How It Effects Genes

In this video, learn how CBD upregulates genes to allow the immune system to function more optimally.

CBD For Sleep

CBD For Sleep

If you’re struggling to sleep, CBD may offer some relief. CBD has been shown to assist with helpful sleep because it helps alleviate conditions that complicate sleep. Calming your central nervous system can have a relaxing effect,

Using CBD may be helpful for improving sleep since CBD has the ability to minimize anxiety through its influence to the 5 HT1A Hydroxytryptamine receptor, which can be helpful in improving restful sleep. including receptors that govern your body’s sleep and wake cycle.

We now have pure Cannabigerol CBG isolate in grams. This molecule is making news as the studies keep showing results. People report 5mg of CBG matches 40mg of CBD for sleep.

Read more about CBD and Sleep from the American Sleep Association HERE!

CBD For The Stomach
CBG Cannabigerol Isolate
CBG Cannabigerol Isolate

azWHOLEistic now carries pure CBG Isolate in grams. This molecule is making news as the studies keep showing results. So, what is CBG? People familiar with cannabis have heard of CBD (Cannabidiol) and THC (tetrahydrocannabinol) and their effects, but did you know there are many similar compounds in cannabis? A lesser-known cannabinoid called CBG (cannabigerol).

Because it is present in low levels (usually less than 1%) in most cannabis strains, CBG is considered a minor cannabinoid. Amazingly, however, THC and CBD start out as CBG—it’s the chemical parent of THC and CBD. Cannabis plants produce cannabigerolic acid (CBGA), the precursor to the three main cannabinoid lines: tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA), and cannabichromenic acid (CBCA).

The Different Delivery Methods For CBD

CBD Tinctures

Tinctures are the most common usage of CBD on the market. The ease of use is key especially at first to be able to determine your personal dosage. Oils allow you to adjust your dose easily by increasing the amount per dropper. The suspension is also important. We have CBD in MCT oil, Grape seed Oil as well as Hemp Seed Oil. Some have natural flavoring like citrus or Peppermint which makes it more enjoyable to consume for those who need flavor.

CBD Oil Concentrates

CBD Concentrates

CBD concentrates typically contain the strongest dosage of CBD compared to any other type of products. It can contain up to 10 times the concentration compared to other CBD products. In comparison to tinctures, concentrates may come in a syringe or just a jar with raw Powder. Concentrates can be ingested orally, added to Yogurt, apple sauce etc, or sprinkled into a strawberry for Parent who have Autistic children who are very specific about what they will and won’t eat.

CBD Capsules

CBD Capsules

Using capsules is convenient, but you should know your dosage first as you cannot cut a gel cap in half. It is much easier to take than tinctures or concentrates. Additionally, if you take vitamins (or any other supplements), you can just add the CBD capsule to your daily supplement regimen.


CBD Topicals

More brands have started to add CBD in topicals, such as lotions, salves, and lip balms, for its skin benefits. CBD topicals have been shown to support skin rejuvenation. Few people realize that what you put “on” your skin does soak into your blood stream. Especially when you incorporate natural emollients that help to open the dermis of the skin. The CBD molecule does go into the blood stream even when applied topically.

CBD Spray

CBD Sprays

CBD sprays are very desirable as they can be sprayed into the oral cavity and absorb from the tongue and cheeks which is a larger surface area than sublingual ( under the tongue ). Sprays are a favorite for those who have situational anxiety and DO NOT want to inhale their CBD into their lungs which is the fastest delivery to the neurological field.


CBD Inhalation

Inhalation, also referred as nebulizing is the fastest delivery to the brain. When you inhale CBD into your lungs, it by-passes the Blood Brain Barrier so it is a direct absorption to the brain. The advantage of this method is key for many people for several reasons.

1. For anyone who requires 100 mg or more of CBD per day, inhalation will typically cost less.

2. We can never predict how much CBD is being absorbed in the blood when taken orally. With inhalation, we know that more material is typically absorbed due to the direct delivery to the lungs.

3. Oils can be absorbed prior to actual digestion, but capsules & edibles take longer as they absorb in the lower intestines so there is some loss during this process.

Broad Spectrum CBD Oils

Broad Spectrum terminology was first used by us in 2018 as a new term.The hemp derived CBD contain smaller amounts of naturally occurring tetrahydrocannabinol ( THC ) which makes you high.


When hemp is grown, it can be used in a whole host of products, including food, clothing, lubricants, fuels, skin and body care items, and supplements – each part of the hemp plant has unique properties. In fact, hemp seed oil contains ZERO CBD. It is all the other components of the plant that contain CBD. There are many ways to extract the oil. In some instances, the oil may be extracted using chemical solvents like butane or hexane. But these harsh chemicals are neurotic and can inhibit the function of your immune system. Fortunately, there are safer ways, like CO2 and other clean extraction processes ( which all our labs utilize ) to obtain the oil from the Hemp plant and be sure there is zero detectable THC.

FULL SPECTRUM OILS contain some THC while BROAD SPECTRUM OILS do not contain any THC. 

The super critical CO2 method uses carbon dioxide under high pressure and extremely low temperatures to isolate, preserve, and maintain the purity of the medicinal oil and when done properly the end product is safe, potent, and free of chlorophyll and other harmful chemicals.

Complete with CBD, CBDV and CBDVa for a wide range of benefits.

Nano Coconut CBD Oils

The size of the particle has a direct effect on the speed of the molecule to be assimilated into the blood stream. Since 2014 when we first began to study and understand their utility, CBD extracts and Hemp Oils have become vital to peoples health supplements.

Nano Coconut CBD oil contains natural saturated fats that increase the good HDL cholesterol in your body. To date, there are over 1,500 studies showing coconut oil to be one of the healthiest foods. Research has finally uncovered the secrets to this high quality food: namely healthy fats called medium-chain fatty acids (MCFAs). Around 62 percent of the oils in coconut are made up of these three healthy fatty acids, and 91 percent of the fat in coconut oil is healthy saturated fat. This fat composition makes it one of the most beneficial fats.

CBD Topicals

TOPICALS are used directly on an area of skin, and can be used on an as needed basis. Select a product based on ONLY natural emollients with or without Menthol and then use as needed. Remember, even a topical will allow the CBD to soak into the blood stream and effect neurological conditions.

CBD Inhalants and Nebulizers

Inhalation is the FASTEST way to deliver cannabinoids to the brain. For a host of neurological conditions. You may experience a range of benefits with these materials. Check out the HOW TO VIDEOS below if you need assistance using these products.

Why CBD Isn't Working For You
What Is THC Delta 8

Delta 8 is an Analog of THC with anxiolytic, appetite stimulating, analgesic and neuroprotective properties. Delta 8 binds to the G Protein coupled receptor CB1 located in the central nervous system and exhibits a lower psychotropic potency than Delta 9 THC which is the primary form of THC.

Both Delta 8 and Delta 9 contain “double bonds” in that region of the carbon atoms chain = Delta 8 bonds in the 8th chain while delta 9 bonds in the 9th chain.

Delta 8 is chemically different from Delta 9 by only a few atomic bonds. Delta 8 only exists in small percentages in the cannabis and Hemp plants.

Like all Cannabinoids Delta 8 influences the endo-cannabinoid system in all mammals and brings on a calming effect through influence to the 5-HT1 Alpha receptor which is also called the Hydroxy tryptamine – serotonin receptor.

The POTENTIAL uses for DELTA 8 are as follows:

  • Pain Relief
  • Appetite Stimulation
  • Nausea
  • Anxiety
  • Neuro Protectants
  • Relaxation
CBD For Pets

CBD For Pets

All “mammals” can benefit by the use of Cannabinoids because we all share the same type of receptors. There are many types of PET TREATS on the market.  Our position is that this is a gimmick, because most contain preservatives and artificial flavors. Bacon flavor DOES NOT make CBD better. Always start the dose low and increase slowly until you see a change in behavior.

We now have pure Cannabigerol CBN isolate in grams. This molecule is making news as the studies keep showing results. If you are planning on taking your pet for a long drive, or your pet suffers from anxiety during the 4th of July or thunderstorms, CBN may be the answer. People report 5mg of CBN matches approximately 40mg of CBD. CBN studies show influence to certain receptors which may be helpful in improving anxiety for your pet.  For dosing it is suggested you start with a low dose.  You may use a micro spoon (shown below) of CBN in your pets meal for easy consumption of this pure organic powder.

Why Does CBD Make Me Feel Good With No THC?
CBD's Secret Of Success

CBD’s Secret to success is the influence over the Blood Brain Barrier.  In a paper published March 2018, scientists demonstrated that attaching drug-carrying nano capsules to CBD — that is, cannabidiol, the minimally psychoactive chemical found in hemp — allowed them to slip them past the blood-brain barrier.

The researchers, from Complutense University of Madrid and The Open University in the UK, performed their experiments both in a lab model of the blood-brain barrier and in real mice, showing that their technique was much more effective at penetrating the blood-brain barrier than existing methods.

CBD Dosing

While we wish we could provide the public with a mathematical CBD dosage calculator, it isn’t quite that simple – EVERYONE IS DIFFERENT and each person’s metabolism is unique. 

With these facts in mind, most people who are new to CBD will begin their journey by starting with the minimal suggested CBD dosage ( 5 mg to 10 mg ) on any product, then gradually increasing the dose until they achieve the desired results.

All of azWHOLEistic’s CBD oils come with a FREE dose card download at purchase of any CBD oil.

For more information on CBD Dosing, watch the video below!

Medical Research On CBD

Thousands of scientific/medical peer-reviewed studies have been carried out specifically on CBD. Project CBD is a non-profit organization strictly dedicated to documenting the research progress.

CBD Trials

Much to the chagrin of some people, there have in fact been many legitimate medical trials regarding CBD. The key is knowing where to look. The fact is that the US Government secured their own Patent for Cannabinoids for inflammation and Neuro-protectants.

You can find a wide range of studies on the website HERE.

What Are The Side Effects of CBD?

Cannabidiol is a 100% natural molecule that influences millions of receptors and regions of the body and brain. CBD is controlled by the nociceptive neurons of the “Immune System” which means causes no harm. Should you experience any unfavorable reactions such as loose stool or light headed, stop taking it or at least “reduce” your dosage as it may be just too much to start.

We suggest people start with 5 to 10 mg per day and “slowly” increase as needed. Each person’s dose is unique to their body. CBD cannot cause “side effects” so if you experience any Side Effects, it is likely caused by something else especially if you are taking any Prescription Medications. It is your responsibility to look up the Side Effects of the Prescriptions medication you are taking as this is likely the reason for any side effect, and consult your Primary Care physician.


What Are Phyto-Nutrients?

Phyto Nutrients including Cannabinoids are responsible for influencing specific receptors within the body and brain and help to govern many chemical modulations conducting a balancing effect. When you take Phyto-Cannabinoid Rich (PCR) nutrients like hemp-derived CBD, you are assisting your body’s natural ability to pool up or increase the production of Anandamide as well as the family of Glutathion molecules. This increase in Glutathion influences 3 things:Reactive Oxygen Species  =

  • Antioxidants
  • Detoxification
  • Protein repair

Additionally CBD helps to turn down Gene’s that are pro-inflammatory like EMF stress, or Peroxy Nitrates and other VOC’s like air pollution. This is called Gene Transcription Modification. CBD stimulates 2AG so it helps increase production of natural cannabinoids while it blocks FAAH which is an enzyme which breaks down Anandamide, i.e. the bliss molecule.

About The Moringa Tree
Moringa Products In Phoenix

Moringa is a fairly large tree that is native to North India. It goes by a variety of names, such as drumstick tree, horse radish tree, or ben oil tree. Almost all parts of the Moringa tree can be eaten or used as ingredients in traditional herbal medicines. The leaves and pods are commonly eaten in parts of India and Africa.

The leaves are an excellent source of many vitamins and minerals. One cup of fresh, chopped leaves (21 grams) contains the following:

Protein: 2 grams.
Vitamin B6: 19% of the RDA.
Vitamin C: 12% of the RDA.
Iron: 11% of the RDA.
Riboflavin (B2): 11% of the RDA.
Vitamin A (from beta-carotene): 9% of the RDA.
Magnesium: 8% of the RDA.

​In Western countries, dried leaves are sold as dietary supplements, in either powder or capsule form. Compared to the leaves, the pods are generally lower in vitamins and minerals. However, they are exceptionally rich in vitamin C. One cup of fresh, sliced pods (100 grams) contains 157% of your daily requirement for vitamin C.

The diets of people in developing nations sometimes lack vitamins, minerals and protein. In these countries, Moringa oleifera can be an important source of many essential nutrients.

Moringa Hair Shampoo
Moringa Hair Shampoo
Moringa Hair Conditioner
Moringa Hair Conditioner

Moringa Is Rich With Antioxidants
Antioxidants are compounds that act against free radicals in our bodies. High levels of free radicals cause oxidative stress, which may contribute to chronic diseases like heart disease and type 2 diabetes.  Several antioxidant plant compounds have been found in the leaves of Moringa oleifera. In addition to vitamin C and beta-carotene, these include:
Quercetin: This powerful antioxidant may help lower blood pressure
Chlorogenic Acid: Also found in high amounts in coffee, chlorogenic acid may help moderate blood sugar levels after meals. In fact, one study in women found that taking seven grams (1.5 teaspoons) of moringa leaf powder every day for three months had significantly increased blood antioxidant levels. Moringa leaf extract may also be used as a food preservative. It increases the shelf life of meat by reducing oxidation.

Moringa Can Lower Blood Sugar Levels
High blood sugar can be a serious health problem. In fact, it is the main characteristic of diabetes. Over time, high blood sugar raises the risk of many serious health problems, including heart disease. For this reason, it is important to keep blood sugar within healthy limits. Interestingly, several studies have shown that Moringa oleifera may help lower blood sugar levels. However, most of the evidence is based on animal studies. The human studies are few, and generally of low quality so if you decide to sample this plant monitor your body along with any positive or negative side effects.

In one study, 30 women took seven grams of Moringa leaf powder every day for three months. This reduced fasting blood sugar levels by 13.5%. Additionally, a small study in six diabetic patients found that adding 50 grams of Moringa leaves to a meal reduced the rise in blood sugar by 21%.

These effects are caused by plant compounds found in Moringa leaves, such as isothiocyanates.

Moringa Can Reduce Inflammation
Inflammation is the body’s natural response to infection or injury. It is essential as a protective mechanism, but may become a major health issue when it goes on for a long time. Sustained inflammation is believed to be involved in many chronic diseases, including heart disease and cancer. Many fruits, vegetables, herbs and spices have known anti-inflammatory effects. These include turmeric and pomegranates. Moringa leaves, pods and seeds have been shown to have anti-inflammatory properties as well, which may also be due to isothiocyanates. However, the research so far has been limited to test tube and animal studies. It remains to be seen if Moringa oleifera has similar anti-inflammatory effects in humans.

Moringa Can Lower Cholesterol
High amounts of cholesterol in the blood have been linked to an increased risk of heart disease. Many plant foods can effectively reduce cholesterol. These include flaxseeds, oats and almonds. Both animal and human studies have shown that Moringa oleifera may have similar cholesterol-lowering effects.


Paul Stamets, visionary mycologist extraordinaire, has discovered several new species of mushrooms and pioneers countless techniques in the field of edible and medicinal mushroom cultivation. He has recently achieved remarkable results cleaning up dangerous toxins using “fungal bioremediation” and radically improving soil fertility with mushrooms.

About Terpenes

Terpenes and terpenoids are the primary constituents of the essential oils of many types of medicinal plants and flowers. Essential oils are used widely as fragrances and in medicine and alternative medicines such as aromatherapy.

We Sell 100% Natural Organic Terpenes To Add To Your Supplements!

Terpenes are known to interact with THC and CBD, the main active compounds in Hemp. Research is showing that terpenes may actually have effects of their own.

There is NO THC in natural Terpenes.

Guide To Terpenes

Terpenes In Phoenix

We now sell Natural Terpenes to flavor your favorite CBD products!

View Our Natural Terpenes Flavors
Terpenes In Phoenix
About Reishi Mushrooms
Reishi Mushroom

Known as the “mushroom of immortality”, Reishi has a long history of use intraditional Chinese medicine where it has been used for over 2000 years to promote rest, relax the mind and enhance vital energy and memory function and support of the respiratory system.

The bioactive Reishi fungus contains important minerals like potassium, calcium, phosphorus, selenium, iron and zinc, as well as all the essential amino acids, especially lysine and leucine. Also present are a variety of polysaccharides and tri-terpenes, which are bioactive compounds with possible beneficial effects on liver health.

Studies have shown these components to also be useful in promoting digestive well-being and, for some individuals, helping maintain blood glucose levels already in the normal range. Evidence also suggests that these compounds may be helpful in boosting the immune system and may discourage oxidative damage by free radicals. The tri-terpenes in particular may also help maintain blood pressure and cholesterol levels already within normal range.

There is almost no “detailed” Western medical literature that thoroughly decodes Reishi. Steven S. Gross, PhD, biomedical researcher at Weill Cornell Medical College — and very liberal-minded man — has stated that “the enormous chemical complexity of fungi and plants makes it essentially impossible to confidently ascribe any observed psychoactivity to a single molecular constituent, site of CNS action, molecular mechanism, or signaling pathway.

A few writings confirm that Reishi is exceptionally high in tri-terpenes, a class of compounds that can affect the nervous system through the liver. But even Iris Benzie, Reishi specialist and chair professor of biomedical science in the department of health technology and informatics at Hong Kong Polytechnic University, admits in her Herbal Medicine: Biomolecular and Clinical Aspects that “very little is known about the enzymes and biochemical pathways involved in their biosynthesis.”

Reishi’s effects are gentle and, like all adaptogens, meant to be built up over time and that its immediate effectiveness can be influenced by a few factors, like the physical health and mentality of the consumer.

We Sell Reishi Powder and Have Seen Amazing Results From Our Clients!


Detoxification of The Human Body

It is unreasonable to expect the majority of people to take this information seriously, but what is mentioned below is 100% factual and has a “direct effect” on the health of your cells and your immune system’s ability to prevent disease.

We are literally bathed in toxins every day and worrying will do nothing to stop it. But you do have the ability to limit your exposure to these toxins by being “aware” of them. Limiting toxins has a direct effect on your quality of life and how frequently you visit the doctor and are prescribed prescription drugs. Your state of mind and “stress” is also a factor with how well your immune system functions to remove toxins from your body.

Relaxation and meditation has a direct effect on the body’s chemistry and can keep your immune system strong. Many of these “common” toxins are things that you can’t see, smell or feel. This is why so few people are even aware of them. We don’t realize that we’re being affected until we come down with a chronic condition after years of subtle and often consistent exposure to a combination of these toxins.

This makes it almost impossible to pinpoint a specific environmental toxin as the source of illness, yet when you look at the facts, the increasing numbers of cancers, immune system disorders, neurological problems, chronic fatigue syndrome, allergies and hormonal disturbances that are facing the nation – toxins are obviously part of the equation. Especially when cancer was present in 1 in 35 people in 1970 and today it is 1 in 3. Consider these statistics:

  • Approximately 77,000 chemicals are produced in North America
  • Over 3,000 chemicals are added to our food supply
  • More than 10,000 chemical solvents, emulsifiers and preservatives are used in food processing
  • 1,000 new chemicals are introduced each year

Where do all of these chemicals end up? They are absorbed into our groundwater, rivers, lakes and oceans, spewed into our air, and added, quite intentionally, to our food supply. A study in last year’s British Medical Journal estimated that perhaps 75 percent of most cancers are caused by environmental and lifestyle factors, including exposure to chemicals. Another report by the Columbia University School of Public Health, estimated that 95 percent of cancer is caused by diet and environmental toxicity. This is really not surprising when you consider that estimates show most Americans have somewhere between 400 and 800 chemicals stored in their bodies, typically in fat cells. Some of the short and long-term effects of these toxins include:

  • Neurological disorders (Parkinson’s, Alzheimer’s, depression, attention deficit disorder, schizophrenia, etc.)
  • Cancer, Nutritional deficiencies, Hormonal imbalances, Enzyme dysfunction, Altered metabolism, Reproductive disorders, Fatigue, Headaches, Obesity, Muscle and vision problems, Immune system depression, Allergies/Asthma, Endocrine disorders, Chronic viral infections.
Brain Detox and Balance
Fake Nails

Hello ladies. The glue that holds your fake nails on is highly toxic and can assimilate into your blood stream. Not only does this glue destroy your natural nails so that you have to cover them up, it could be slowly killing you.

If the nail tech is wearing a mask, don’t you think the toxic gas might be bad for you?  It is possible that the chemicals used during your weekly / monthly nail visit is causing your condition.

Shampoos and Conditioners

Most products sold in the super market are made with sulfates and fillers that can be toxic to your body. Experts will tell you that you do not need to shampoo your hair daily. In fact your body secretes healthy oils to your scalp that are actually good for you and washing these healthy oils away too frequently can actually prevent your body from doing what it wants to do naturally. It can also cause follicles to become clogged.

​Vanity has its price!

Green Virgin Moringa, Soapnut and Citrus Shampoo
Green Virgin Moringa Oil and Citrus Conditioner
Swimming Pools and Chlorine
CBD Studio - Swimming Pools Are Toxic

That beautiful pool is filled with water and Chlorine is the chemical that controls bacteria and algae from forming. Technically that algae is not as bad for you as the chlorine that controls it. Keeping a moderate level of Chlorine and pH balance is important. Don’t let your Chlorine levels get too high and don’t swim in the pool after shocking it.

Remember your body will absorb the Chlorine molecule which ends up inside your cells forcing your “immune system” to work overtime.

Toxic Footprint and Exposure To Toxins
Clothing Off Gasing

Clothing made of rayon, blended cotton, corduroy, wrinkle-resistant 100% cotton, and any synthetic blended polymer are likely to have been treated with formaldehyde resins, which is a “probable carcinogen.” You can be exposed to the chemical both via off-gassing and direct contact with your skin.

As illustrated by recent lawsuits against lingerie giant Victoria’s Secret, undergarments containing formaldehyde can create nagging health problems. Formaldehyde has been shown to cause cancer in animals, and may cause cancer in humans. Other common adverse health effects include fatigue, skin rashes, and allergic reactions.

How Toxins Get In Our Food
Material Off-Gassing

NEW CARS – Yes, all new cars have a wide range of toxic chemicals in the plastics and foam used in their manufacturing process.

CARPET – Indoor carpeting has recently come under greater scrutiny because of the volatile organic compounds (VOCs) associated with new carpet installation. The glue and dyes used with carpeting are known to emit VOCs, which can be harmful to your health in high concentrations. However, the initial VOC emissions will often subside after the first week following installation, so vent the house very well after installation.


AIR FRESHENERS – Air fresheners and cleaning solutions, when used excessively or in a small, non ventilated area, can release toxic levels of pollutants. This comes from two main chemicals called ethylene-based glycol ethers and terpenes. While the EPA regards the ethers as toxic by themselves, the non-toxic terpenes can react with ozone in the air to form a highly poisonous combination. Air fresheners in particular are linked to many volatile organic compounds, such as nitrogen dioxide.


MATTRESS –  Flame retardants commonly used in mattresses, upholstery, television, and computer casings and circuit boards, flame retardants use polybrominated diphenyl ethers, or PBDEs for short. Two forms of PBDEs were phased out of use in manufacturing in the United States in 2004 because of related health threats, but the products containing them linger on.

Studies have linked PBDEs to learning and memory problems, lowered sperm counts and poor thyroid functioning in rats and mice. Other animal studies have indicated that PBDEs could be carcinogenic in humans. A person sleeping on a chemically treated mattress will absorb 0.8 mg of antimony every night; an amount that is 27 times more than the U.S. Environmental Protection Agency says is safe. Five-year-old children, meanwhile, will absorb 0.5 mg of antimony every night, according to CPSC, which is 63 times more than the EPA’s safety limit.

Shopping for a safe mattress is not an easy task. Most Mattress manufacturers are not required to label or disclose which chemicals their mattresses contain. However, there are now a few manufacturers that make 100% wool, organic and toxin-free mattresses. Another option that seems reliable is finding a mattress that uses a Kevlar, bullet-proof type of material in lieu of chemicals for fire-proofing. These are available in most big stores, and will help you to avoid some of the toxicity.


​HAIR SPRAYS – Most hair sprays are toxic to breath and also will find their way into your blood stream from ending up on your skin and scalp. Choose your hair care products wisely and use as little as possible.

CLOTHING – Clothing made of rayon, blended cotton, corduroy, wrinkle-resistant 100% cotton, and any synthetic blended polymer are likely to have been treated with formaldehyde resins, which is a “probable carcinogen.” You can be exposed to the chemical both via off-gassing and direct contact with your skin.

As illustrated by recent lawsuits against lingerie giant Victoria’s Secret, undergarments containing formaldehyde can create nagging health problems. Formaldehyde has been shown to cause cancer in animals, and may cause cancer in humans. Other common adverse health effects include fatigue, skin rashes, and allergic reactions.


Baking Soda For Cancer?
Heart Disease Causing Parasite Infiltrating America

A parasitic disease commonly transmitted in the feces of a bloodsucking insect in South America, Central America, and Mexico now affects an estimated 300,000 people in the United States, according to a scientific statement from American Heart Association scientists. Though the illness, called Chagas disease, can cause heart failure in serious cases, it has received little attention in North America. Now, warn the researchers in the journal Circulation, it’s time for doctors to be vigilant.

Chagas is transmitted by a parasite called Trypanosoma cruzi, which dwells in the feces of Triatomine bugs. Also known as “kissing bugs.” Triatomines are native to Central and South America but have slowly been spreading northward for over 40 years. Currently, Chagas disease affects some 300,000 Americans, but that number could rise. The US Centers for Disease Control has confirmed sightings of kissing bugs throughout the midwestern and southern states, but Dr. Maria Carmo Pereira Nunes, a co-author of the report, tells Inverse that there are a few states that are particularly at risk, including Texas, New York, Florida and California, which she says have each documented over 10,000 cases of Chagas disease.

“Many physicians consider Chagas to be a disease that is restricted to Mexico and Latin America, and this assumption causes general practitioners in the United States and Europe to ignore the condition when making a differential diagnosis of cardiomyopathies,” she says.

These bugs are pretty nightmarish. They’re called kissing bugs because they bite humans on the lips and eyes, according to researchers at Texas A&M, which causes local swelling and opens up a small wound. Biting in itself doesn’t cause Chagas disease; it’s passed on when a person is bitten by an infected insect and then the bug happens to poop near the area where it bites you. Fortunately, not all kissing bugs carry T. cruzi]( — Texas A&M estimates 55 percent of them are infected — and the new report notes that between 60 and 70 percent of people infected with Chagas don’t develop any symptoms at all.

The initial symptoms that the CDC are pretty nondescript, including fever, fatigue, body aches, headache, and rash. Upon physical examination, a doctor might find that an infected person’s liver, spleen, or glands are enlarged, and there’s usually telltale swelling at the site of the bite where the bug poop got rubbed in. Though these symptoms often go away on their own, the T. cruzi infection lingers and can cause much more serious damage if left untreated.

Serious infection can actually change the muscle tissue in the heart, causing it to enlarge in about one-third of cases. This condition, cardiomyopathy, can lead to potential heart conditions down the line, like stroke. In some cases, it can mean sudden death .

Early Detection Scans
Thermography Breast Scan
Thermography Body Scan

Full Spectrum Thermography Scans for safe and effective early detection. 

Mammograms have been proven to increase the risk of Cancer due to several factors.
1. High Radiation focused on the breast
​2. Pressure can rupture benign cysts
3. Pressure can rupture hidden tumors quickly metastasizing the cancer enabling it to spread faster throughout the body instead of healing.

Full Spectrum Thermography is a “non invasive” and comfortable process of locating areas where health problems are developing.

Thermal Imaging is the safest process for early detection in men & woman.

What You Need To Know About Cheese
Ketamine's Link To Opioids Changes Perspective

In a paper published Wednesday, a team of psychiatrists and anesthesiologists showed that ketamine’s rapid effects are due, at least in part, to its activation of the opioid receptors. Amid the ongoing opioid crisis in the United States, this finding could serve to complicate the redemption narrative that ketamine is currently enjoying in the public eye.

“We think ketamine is acting as an opioid,” Alan Schatzberg, M.D., a professor of psychiatry and behavioral sciences at Stanford University and one of the study’s authors, tells NPR. “That’s why you’re getting these rapid effects.”

Schatzberg has received research funding from Janssen, the lab that conducted the Phase 2 clinical trial on a ketamine nasal spray, as well as from several other drug companies. To do this double-blind crossover study, he and his colleagues gave 12 volunteers with treatment-resistant depression one of two pills before injecting them with ketamine: either a placebo or a dose of naltrexone, a drug that blocks drugs from binding with opioid receptors. This study design allowed the researchers to measure whether ketamine’s binding to opioid receptors is necessary for its antidepressant action. Since the experiment was a crossover study, participants received both treatments at different points in time.

The subjects whose opioid receptors weren’t blocked before getting ketamine — those who got the placebo — reported much stronger reductions in depression measures than the patients who took naltrexone. However, the latter did still experience reduced depression, suggesting that ketamine’s action may not be totally opioid-related.

An average of 33 days later, the subjects returned to receive the other treatment condition — if they got a placebo the first time, this time they got naltrexone, and vice versa. After looking at the results of that treatment, the researchers concluded that their findings supported their opioid hypothesis: Ketamine-induced reductions in depressive symptoms were far stronger when the opioid receptors weren’t blocked.

Nicotine: How To QUIT!
Quit Smoking With CBD


Nicotine was isolated from tobacco leaves (Nicotiana tabacum) in 1828, but the powerful effects of nicotine were already well recognized. The tobacco plant is native to the Americas and its use as a medicine and stimulant goes back at least 2000 years and most likely many millennia before that. South American temple carvings show Mayan priests enjoying the benefits of this drug from smoking tobacco through a pipe. Nicotine was first extracted from tobacco by German physicians Wilhelm Heinrich Posselt and Karl Ludwig Reimann. Nicotine is a strong alkaloid, in its pure form is a clear liquid with a characteristic odor. It turns brown on exposure to air. It is water soluble and separates preferentially from organic solvents. It is an amine composed of pyridine and pyrrolidine rings.

In 1763 nicotine was first used as an insecticide to poison insects.

Nicotine is a dibasic compound and the availability and absorption in human body depends upon the pH of the solution. The absorption can occur through oral mucosa, lungs, skin or gut. The increase in pH of a solution causes an increase in concentrations of uncharged lipophilic nicotine, in this form it can actively pass through all biological membranes.


Tobacco consumption alone accounts for nearly 5.4 million deaths per year and one billion people may die in this century if global tobacco consumption remained at the current levels. An international treaty spearheaded by WHO in 2003 and signed by 170 countries, aims to encourage governments to reduce the production, sales, distribution advertisement and promotion of tobacco products. Despite strong opposition from the industry, the treaty has been making steady progress in achieving its goal of comprehensive tobacco control around the world.

As tobacco consumption is being curbed, there is a growing demand for cessation and Pharmacological treatment of nicotine addiction remains an active area of research. There are many nicotine preparations (nicotine gums, patches, e cigarettes and inhalational agents) that are freely available in most parts of the world.

E-cigarettes are a nicotine delivery system which delivers nicotine in a vapor form and it closely mimics the act of smoking. Currently, these products constitute approximately 1% of total nicotine consumption and are showing an increasing trend in most countries. Titration, or the ability to wean off or slowly reduce nicotine delivery on a weekly or monthly basis makes it a highly viable choice for Nicotine Reduction.


MANY PEOPLE THINK THAT SMOKING HELPS THEM RELAX This is 100% untrue. The fact is that Nicotine is a stimulant and the higher the levels of Nicotine in the body, the more stressed you will be. The act of smoking is “primarily” an oral fixation. The action of smoking makes you think it is helping you cope with stress, but inside the body another problem is occurring.

Nicotine is probably the most addictive drug readily available to the average person. The nicotinic effects from smoking are highly reinforcing, with some users comparing the effects to cocaine or amphetamine. Regular smokers consume nicotine for stimulation but also to avoid the withdrawal effects. The withdrawal effects include irritability, anxiety, restlessness, impatience, increased appetite and weight gain.


Nicotine also affects the developing fetus. Adverse effects of chronic nicotine consumption during pregnancy include reduced infant birth weight, attention deficit disorders, ADHD and other cognitive problems. Nicotine receptors are expressed early during development, and it is not completely clear what effects nicotine exposure during development has on the fetus. The health effects of nicotine cannot be entirely separated from the effects of cigarettes as a whole. Nicotine keeps people smoking, but the many other compounds found in cigarettes that are inhaled when smoking contribute to respiratory disease, cardiovascular disease, and lung cancer. The average Cigarette sold in America has a minimum of 300 to a maximum of 1,200 chemicals many of which are carcinogenic to human cells.

Many of these chemicals are designed to target the brain and increase “desire” to smoke more, thus keeping the individual paying for more. A complete understanding of the carcinogenic properties of nicotine alone have yet to be evaluated independent of tobacco smoke. Possibly as a result of the tax benefits to the overall economic position. Gastrointestinal effects are less severe but can occur even after respiratory exposure. Predominant immediate effects as seen in animal studies and in humans consist of increase in pulse rate and blood pressure. Nicotine also causes an increase in plasma free fatty acids, hyperglycemia, and an increase in the level of catecholamines in the blood. There is reduced coronary blood flow but an increased skeletal muscle blood flow due to the stimulus nature of the compound. The increased rate of respiration causes hypothermia, a hypercoagulable state, decreases skin temperature, and increases the blood viscosity.

Nicotine is one of the most toxic of all poisons and has a rapid onset of action. Apart from local actions, the target organs are the peripheral and central nervous systems. In severe poisoning, there are tremors, prostration, cyanosis, dypnoea, convulsion, progression to collapse and coma. Even death may occur from paralysis of respiratory muscles and/or central respiratory failure in adults of around 30-60 mg of nicotine.


Nicotine is one of the most addicting agents. The US surgeon general (2010) has concluded nicotine to be as addictive as cocaine or heroin. Nicotine interacts with the nicotinic acetyl choline receptors and stimulates the dopaminergic transmission. This in turn stimulates the reward center in the brain and is responsible for the mood elevation and apparent temporary improvement in cognitive function. With chronic stimulation by nicotine the GABAergic neurons are desensitized and thus lose their inhibitory effect on dopamine.

This in turn reinforces the addiction by inducing craving. This effect has been shown to affect the CYP2A6 gene and leads to heritable dependence to nicotine.


Nicotine causes catecholamine release and stimulates the autonomic system. There is increased glycogen synthesis due to α-adrenoceptor stimulation. This leads to reduction in the fasting blood glucose levels. It also causes lipolysis thus decreasing body weight. Nicotine affects insulin resistance and predisposes to metabolic syndrome. Studies show prenatal exposure was toxic to pancreatic β-cell and leads to decreased B cell population, thus increasing the risk of diabetes.

Nicotine forms arachidonic acid metabolites which causes increased cell division. Binding to Bcl-2 and action on vascular endothelial growth factor and cyclooxygenase-2 (COX-2) causes increased cancer proliferation and survival.

Anyone diagnosed with any cancer should wean off Nicotine as soon as possible for greater opportunity to survive cellular degradation and the spread of cancer.

We specialize in helping people wean off nicotine and have had over 95% success helping people quit smoking ​in the last 3 years.

7 Top Foods Cardiologists Love

Cardiovascular disease remains the leading cause of death in the U.S. The numbers make this reality even more frightening. Studies done by the American Heart Associations how that 1,400,000 people die from heart disease annually, and 2600 Americans die daily. Maintaining optimal heart health is not something to take lightly. We all deserve to live long, healthy, fruitful lives, which requires being mindful of the foods you’re putting into your body. In the diet-crazed world we live in, let’s not only prioritize slimming our waists and trimming our belly fat. It’s tremendously important to protect our hearts (literally and figuratively).

Oats and Barley
“Oats and barley contain a special type of soluble fiber called beta-glucan, which has a host of benefits for heart and human health,” explains Segal. “Beta-glucans bind to bile acids and cholesterol in the intestines and prevent their absorption into the body. So if you have high cholesterol, it would be a good idea to incorporate oats or oatmeal for breakfast on a regular basis. Beta-glucans are also found in seaweed, baker’s yeast, and various species of mushrooms such as reishi, shiitake, and maitake.”

“Salmon and other fatty fish like fish oils, especially omega-3 fatty acids, are critical for maintaining a healthy heart,” explains Segal. “Fatty fish such as salmon, albacore tuna, mackerel, herring, lake trout, and sardines, and crustaceans such as lobster, oysters, and squid are the protein staples of a heart-healthy diet. They all contain health-protective omega-3s, specifically the long-chain variety known as LC omega-3, which contains eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA). Long-chain omega-3s have been shown in human clinical trials to prevent heart attacks by helping the heart maintain its rhythm. Studies show that they also make blood less likely to clot, lower blood pressure, keep blood vessels healthy and less likely to narrow, reduce triglycerides, and lower inflammation.”

Dark Leafy Greens
“Salad greens, spinach, kale, Swiss chard, collard, and mustard greens are rich in vitamins A, C, E, and K and contain antioxidants that help rid toxins from the body,” says Segal. “But it’s their abundance of calcium, magnesium, and potassium that truly makes them heart-healthy. Potassium is known to help with limiting the effects of sodium on blood pressure, along with magnesium and calcium, help the walls of the blood vessels relax, which increases blood flow and reduces blood pressure. Plus, greens, like most vegetables, are full of fiber, which helps lower cholesterol levels.”

Nuts and Seeds
“Unsalted seeds and nuts are also high in potassium, magnesium, and other minerals known to reduce blood pressure.”

“Avocados are a rich source of monounsaturated fatty acids, which can lower both your total cholesterol and your ‘bad’ cholesterol (LDL) while maintaining your ‘good’ cholesterol (HDL) levels,” explains Segal. “They can also benefit insulin control, which can be very helpful to those with prediabetes or type 2 diabetes.”

Olive Oil
“Monounsaturated fatty acids are a mainstay of the Mediterranean diet, which has been shown to improve heart health and brain health, lower risk for breast cancer, and increase longevity,” confirms Segal. “Olive oil is rich in monounsaturated fatty acids and has been shown to reduce blood pressure and both bad cholesterol and triglycerides while increasing good cholesterol.”

“Legumes, which include all kinds of beans, lentils, chickpeas, and black-eyed peas,” are great for heart health according to Segal. “Legumes help the heart because of their high levels of soluble fiber, which is known to lower both cholesterol and triglyceride levels in the bloodstream. Soluble fiber binds to extra LDL cholesterol in the body and disposes it in the form of waste. Legumes contain no cholesterol and are only about 3% fat. They are full of iron, manganese, copper, B vitamins, magnesium, zinc, and phosphorous, and they are very low on the glycemic index, which means they have less effect on your blood sugar. They are also extremely high in protein. For example, a half-cup of some legumes has eight grams of protein.”
We all need reminders of the foods we should be eating in moderation or avoiding altogether. Segal breaks down the foods that aren’t the healthiest for our hearts below.

You Should Eat Less of Anything With Trans Fats, and Here’s Why
According to Segal, trans fat raises your LDL (“bad”) cholesterol and lowers your HDL (“good”) (HDL) cholesterol. “A diet laden with trans fat increases your risk of heart disease, the leading killer of men and women,” warns Segal. “The manufactured form of trans fat, known as partially hydrogenated oil, is found in a variety of food products.”

These are the foods high in trans fat:
1. Yummy Baked goods. “Most cakes, cookies, pie crusts, and crackers contain shortening, which is usually made from partially hydrogenated vegetable oil. Ready-made frosting is another source of trans fat.

2. Yummy Snacks. Potato, corn, and tortilla chips often contain trans fat. And while popcorn can be a healthy snack, many types of packaged or microwave popcorn use trans fat to help cook or flavor the popcorn.

3. Yummy Fried food. Foods that require deep frying like French fries, doughnuts, and fried chicken, can contain trans fat from the oil used in the cooking process.

4. Yummy Refrigerated dough. Products such as canned biscuits and cinnamon rolls often contain trans fat, as do frozen pizza crusts.

5. Creamer and Margarine. Nondairy coffee creamer and stick margarine also may contain partially hydrogenated vegetable oils.

According to a Cardiologist, Here’s What You Need to Do to Have the Healthiest Heart
“Eat a mostly plant- and fish-based Mediterranean diet free of as many processed foods and added sugars as you can,” suggests Segal. “Try to limit the refined processed carbohydrates to rare treats, exercise daily for at least 30 minutes with aerobic exercise at least five to six days out of the week”. The more you exercise, the better it is for lowering cholesterol, stress, inflammation, and potential abnormal heart rhythms. There are rare times where I do use magnesium for certain abnormal heart rhythms. I also advise some intermittent fasting to aid in weight loss, blood pressure, and cholesterol control.”

How Big Pharma Took Over The American Medical Association
The FDA's User Drug Prescription Fee Act

The FDA & User Drug Prescription Fee Act.  This prevents people from getting worth while treatments, and allows Big Pharma to control all medicine.

Low Protein Diet May Prolong Your Life


Fasting. Time-restricted eating. Eating for five days, then fasting for two. Lately it appears everyone is interested in some sort of calorie-restricted diet to better their chances for a longer life with fewer chronic diseases. But what if …


Meat is STILL Bad...Sorry.


A pair of new studies out Monday might nudge you to reevaluate your meat-eating habit. One study found evidence that eating at least two weekly servings of red meat, particularly processed meat, is linked to a slightly higher risk of cardiovascular …


Food Allergies and Blood Types



Click HERE for the latest Hemp Industry Association of America News.



Self Healing Is Possible

The traditional medical system in the United States doesn’t recognize “any” energy fields, nor does it work with, or ​educate people about it.

This then, is a big part of the problem. Part of a healthy lifestyle includes educating yourself about the many proven modalities of natural healing. When you are either consumed by or distracted by too much social media, politics and other stressful situations, you cannot balance your bodies energy and focus on time to heal.

Everything is “energy” and vibrations and once you understand this, you can begin to optimize your body, mind and spirit for increased health. There are literally thousands of methods of healing your body naturally. Unfortunately the majority of people just go see their doctor when they feel ill and do whatever the doctor says.  This has led to a crisis in America and has not helped people learn how to heal naturally. Prescription medications deplete vital nutrients and minerals in the body and Statin drugs for cholesterol deplete Co Q 10 which is important for cellular health. Learn more about energy healing below.


Unleashing The Immune System To Cure Cancer

Nobel Laureates in Medicin 2018, Stockholm, Sweden, December 2018 Press conference.  Source James P. Allison EM1B5525  Author Bengt Nyman from Vaxholm, Sweden  This file is licensed under the Creative Commons

James P. Allison believed that unleashing the immune system was a way to beat cancer when almost no one else did. A Nobel Prize and a growing list of cancer survivors vindicate him.




The ICRS is a group of International PhD’s who have been expanding studies and sharing information about Cannabinoids. WARNING: It does get a bit technical.  We’d be happy to answer any questions you may have.

CBD in the Treatment of Post-Traumatic Stress Disorder


Cannabidiol (CBD) is a non-psychotomimetic cannabinoid compound that is found in plants of the genus Cannabis. Preclinical research has suggested that CBD may have a beneficial effect in rodent models of post-traumatic stress disorder (PTSD). This effect is believed to be due to the action of CBD on the endocannabinoid system. CBD has seen a recent surge in research regarding its potential value in a number of neuro-psychiatric conditions. This is the first study to date examining the clinical benefit of CBD for patients with PTSD.

© PubMed


CBD in Anxiety and Sleep: A Large Case Series


Cannabidiol (CBD) is one of many cannabinoid compounds found in cannabis. It does not appear to alter consciousness or trigger a “high.” A recent surge in scientific publications has found preclinical and clinical evidence documenting value for CBD in some neuropsychiatric disorders, including epilepsy, anxiety, and schizophrenia. Evidence points toward a calming effect for CBD in the central nervous system. Interest in CBD as a treatment of a wide range of disorders has exploded, yet few clinical studies of CBD exist in the psychiatric literature.

Vanilloid TRPV1 Receptor Mediates The Antihyperalgesic Effect of The Nonpsychoactive Cannabinoid, Cannabidiol, In A Rat Model of Acute Inflammation.

Cannabidiol (CBD), a nonpsychoactive marijuana constituent, was recently shown as an oral antihyperalgesic compound in a rat model of acute inflammation. We examined whether the CBD antihyperalgesic effect could be mediated by cannabinoid receptor type 1 (CB1) or cannabinoid receptor type 2 (CB2) and/or by transient receptor potential vanilloid type 1 (TRPV1). Rats received CBD (10 mg kg(-1)) and the selective antagonists: SR141716 (N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide) for CB1, SR144528 (N-[(1S)-endo-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl]-5-(4-chloro-3-methylphenyl)-1-(4-methylbenzyl)pyrazole-3 carboxamide) for CB2 and capsazepine (CPZ) for TRPV1 receptors. The intraplantar injection of carrageenan in rats induced a time-dependent thermal hyperalgesia, which peaked at 3 h and decreased at the following times. CBD, administered 2 h after carrageenan, abolished the hyperalgesia to the thermal stimulus evaluated by plantar test. Neither SR141716 (0.5 mg kg(-1)) nor SR144528 (3 and 10 mg kg(-1)) modified the CBD-induced antihyperalgesia; CPZ partially at the lowest dose (2 mg kg(-1)) and fully at the highest dose (10 mg kg(-1)) reversed this effect. These results demonstrate that TRPV1 receptor could be a molecular target of the CBD antihyperalgesic action.

© Copyright Pub Med

Endocannabinoid 2-Arachidonoylglycerol Suppresses LPS-Induced Inhibition of A-Type Potassium Channel Currents

​Inflammation plays a pivotal role in the pathogenesis of many diseases in the central nervous system. Caudate nucleus (CN), the largest nucleus in the brain, is also implicated in many neurological disorders. 2-Arachidonoylglycerol (2-AG), the most abundant endogenous cannabinoid, has been shown to exhibit neuroprotective effects through its anti-inflammatory action from some proinflammatory stimuli. However, the neuroprotective mechanism of 2-AG is complex and has not been fully understood. A-type K(+) channels critically regulate neuronal excitability and have been demonstrated to be associated with some nervous system diseases. The aim of this study was to explore whether A-type K(+) channels were involved in neurotoxicity of lipopolysaccharides (LPS) and the neuroprotective mechanism of 2-AG in CN neurons. Whole cell patch clamp recording was used to investigate the influence of LPS on the function of A-type K(+) channels and its modulation by 2-AG in primary cultured rat CN neurons. Our findings showed that in cultured CN neurons, LPS significantly decreased the A-type potassium currents (I A) in a voltage-insensitive way. The further data demonstrated that an elevation of 2-AG levels by directly applying exogenous 2-AG or inhibiting monoacylglycerol lipase (MAGL) to prevent 2-AG hydrolysis was capable of suppressing the LPS-induced inhibition of IA and the action of 2-AG is mediated through CB1 receptor-dependant way. The study provides a better understanding of inflammation-related neurological disorders and suggests the therapeutic potential for 2-AG for the treatment of these diseases.

© Copyright Pub Med

Aberrant Epilepsy-Associated Mutant Nav1.6 Sodium Channel Activity Can Be Targeted With Cannabidiol.

Mutations in brain isoforms of voltage-gated sodium channels have been identified in patients with distinct epileptic phenotypes. Clinically, these patients often do not respond well to classic anti-epileptics and many remain refractory to treatment. Exogenous as well as endogenous cannabinoids have been shown to target voltage-gated sodium channels and cannabidiol has recently received attention for its potential efficacy in the treatment of childhood epilepsies. In this study, we further investigated the ability of cannabinoids to modulate sodium currents from wild-type and epilepsy-associated mutant voltage-gated sodium channels. We first determined the biophysical consequences of epilepsy-associated missense mutations in both Nav1.1 (arginine 1648 to histidine and asparagine 1788 to lysine) and Nav1.6 (asparagine 1768 to aspartic acid and leucine 1331 to valine) by obtaining whole-cell patch clamp recordings in human embryonic kidney 293T cells with 200 μM Navβ4 peptide in the pipette solution to induce resurgent sodium currents. Resurgent sodium current is an atypical near threshold current predicted to increase neuronal excitability and has been implicated in multiple disorders of excitability. We found that both mutations in Nav1.6 dramatically increased resurgent currents while mutations in Nav1.1 did not. We then examined the effects of anandamide and cannabidiol on peak transient and resurgent currents from wild-type and mutant channels. Interestingly, we found that cannabidiol can preferentially target resurgent sodium currents over peak transient currents generated by wild-type Nav1.6 as well as the aberrant resurgent and persistent current generated by Nav1.6 mutant channels. To further validate our findings, we examined the effects of cannabidiol on endogenous sodium currents from striatal neurons, and similarly we found an inhibition of resurgent and persistent current by cannabidiol. Moreover, current clamp recordings show that cannabidiol reduces overall action potential firing of striatal neurons. These findings suggest that cannabidiol could be exerting its anticonvulsant effects, at least in part, through its actions on voltage-gated sodium channels, and resurgent current may be a promising therapeutic target for the treatment of epilepsy syndromes.

© Copyright Pub Med

Severity of Alcohol Dependence Is Associated With The Fatty Acid Amide Hydrolase
The endocannabinoid system plays an important role in reward and addiction. One of the two main endocannabinoid neurotransmitters, anandamide, is metabolized by fatty acid amide hydrolase, an enzyme with a functional genetic polymorphism (FAAH Pro129Thr, rs324420). The Thr129 allele has been linked to problem drug and alcohol use, but the association has not been widely replicated and may be stronger for clinical measures of severity rather than categorical diagnosis. In the present study, we sought to determine whether the Thr129 allele was associated with both alcohol dependence (AD) diagnosis and severity in a sample of 1434 European American and African American individuals, 952 of whom were diagnosed with lifetime AD. Participants were genotyped for FAAH rs324420, and ancestry was determined via a genome-wide panel of ancestry informative markers. Subjects participated in Structured Clinical Interviews for psychiatric disorders and 90-day Timeline Followback interviews to assess recent alcohol use. European American participants with current AD had a higher Thr129 allele frequency than non-dependent controls. In European Americans with lifetime AD, there were significantly different distributions of drinking days and binge drinking days between the two genotype groups, with Thr129 carriers reporting a median of 10 fewer abstinent days and 13 more binge drinking days than Pro129/Pro129 homozygotes. In African American participants, there were no significant differences between Thr129 allele frequency in cases and controls and no significant differences in measures of AD severity by genotype. These findings provide evidence that the Pro129Thr missense variant is associated with AD severity in European Americans.


© Copyright PUB MED

Cannabidiol, A Novel Inverse Agonist For GPR12

GPR12 is a constitutively active, Gs protein-coupled receptor that currently has no confirmed endogenous ligands. GPR12 may be involved in physiological processes such as maintenance of oocyte meiotic arrest and brain development, as well as pathological conditions such as metastatic cancer. In this study, the potential effects of various classes of cannabinoids on GPR12 were tested using a cAMP accumulation assay. Our data demonstrate that cannabidiol (CBD), a major non-psychoactive phytocannabinoid, acted as an inverse agonist to inhibit cAMP accumulation stimulated by the constitutively active GPR12. Thus, GPR12 is a novel molecular target for CBD. The structure-activity relationship studies of CBD indicate that both the free hydroxyl and the pentyl side chain are crucial for the effects of CBD on GPR12. Furthermore, studies using cholera toxin, which blocks Gs protein and pertussis toxin, which blocks Gi protein, revealed that Gs, but not Gi is involved in the inverse agonism of CBD on GPR12. CBD is a promising novel therapeutic agent for cancer, and GPR12 has been shown to alter viscoelasticity of metastatic cancer cells. Since we have demonstrated that CBD is an inverse agonist for GPR12, this provides novel mechanism of action for CBD, and an initial chemical scaffold upon which highly potent and efficacious agents acting on GPR12 may be developed with the ultimate goal of blocking cancer metastasis.

​© Copyright PUB MED

Crystal Structures of Agonist-Bound Human Cannabinoid Receptor CB1

The cannabinoid receptor 1 (CB1) is the principal target of the psychoactive constituent of marijuana, the partial agonist Δ9-tetrahydrocannabinol (Δ9-THC)1. Here we report two agonist-bound crystal structures of human CB1 in complex with a tetrahydrocannabinol (AM11542) and a hexahydrocannabinol (AM841) at 2.80 Å and 2.95 Å resolution, respectively. The two CB1–agonist complexes reveal important conformational changes in the overall structure, relative to the antagonist-bound state2, including a 53% reduction in the volume of the ligand-binding pocket and an increase in the surface area of the G-protein-binding region. In addition, a ‘twin toggle switch’ of Phe2003.36 and Trp3566.48 (superscripts denote Ballesteros–Weinstein numbering3) is experimentally observed and appears to be essential for receptor activation. The structures reveal important insights into the activation mechanism of CB1 and provide a molecular basis for predicting the binding modes of Δ9-THC, and endogenous and synthetic cannabinoids. The plasticity of the binding pocket of CB1 seems to be a common feature among certain class A G-protein-coupled receptors. These findings should inspire the design of chemically diverse ligands with distinct pharmacological properties.

© Copyright International Journal of Science

Membrane-Mediated Action of The Endocannabinoid Anandamide On Membrane Proteins

Endocannabinoids are amphiphilic molecules that play crucial neurophysiological functions acting as lipid messengers. Antagonists and knockdown of the classical CB1 and CB2 cannabinoid receptors do not completely abolish many endocannabinoid activities, supporting the idea of a mechanism independent of receptors whose mode of action remains unclear. Here we combine gramicidin A (gA) single channel recordings and membrane capacitance measurements to investigate the lipid bilayer-modifying activity of endocannabinoids. Single channel recordings show that the incorporation of endocannabinoids into lipid bilayers reduces the free energy necessary for gramicidin channels to transit from the monomeric to the dimeric conformation. Membrane capacitance demonstrates that the endocannabinoid anandamide has limited effects on the overall structure of the lipid bilayers. Our results associated with the theory of membrane elastic deformation reveal that the action of endocannabinoids on membrane proteins can involve local adjustments of the lipid/protein hydrophobic interface. The current findings shed new light on the receptor-independent mode of action of endocannabinoids on membrane proteins, with important implications towards their neurobiological function.

© Copyright Pub Med

Hydrolase Domain 6 In The Ventromedial Hypothalamus Controls Energy Metabolism Flexibility


α/β-Hydrolase domain 6 (ABHD6) is a monoacylglycerol hydrolase that degrades the endocannabinoid 2-arachidonoylglycerol (2-AG). Although complete or peripheral ABHD6 loss of function is protective against diet-induced obesity and insulin resistance, the role of ABHD6 in the central control of energy balance is unknown. Using a viral-mediated knockout approach, targeted endocannabinoid measures, and pharmacology, we discovered that mice lacking ABHD6 from neurons of the ventromedial hypothalamus (VMHKO) have higher VMH 2-AG levels in conditions of endocannabinoid recruitment and fail to physiologically adapt to key metabolic challenges. VMHKO mice exhibited blunted fasting-induced feeding and reduced food intake, energy expenditure, and adaptive thermogenesis in response to cold exposure, high-fat feeding, and dieting (transition to a low-fat diet). Our findings identify ABHD6 as a regulator of the counter-regulatory responses to major metabolic shifts, including fasting, nutrient excess, cold, and dieting, thereby highlighting the importance of ABHD6 in the VMH in mediating energy metabolism flexibility.

© Copyright Pub Med

Cannabinoid Type 2 Receptors Mediate a Cell Type-Specific Plasticity In The Hippocampus

Endocannabinoids (eCBs) exert major control over neuronal activity by activating cannabinoid receptors (CBRs). The functionality of the eCB system is primarily ascribed to the well-documented retrograde activation of presynaptic CB1Rs. We find that action potential-driven eCB release leads to a long-lasting membrane potential hyperpolarization in hippocampal principal cells that is independent of CB1Rs. The hyperpolarization, which is specific to CA3 and CA2 pyramidal cells (PCs), depends on the activation of neuronal CB2Rs, as shown by a combined pharmacogenetic and immunohistochemical approach. Upon activation, they modulate the activity of the sodium-bicarbonate co-transporter, leading to a hyperpolarization of the neuron. CB2R activation occurred in a purely self-regulatory manner, robustly altered the input/output function of CA3 PCs, and modulated gamma oscillations in vivo. To conclude, we describe a cell type-specific plasticity mechanism in the hippocampus that provides evidence for the neuronal expression of CB2Rs and emphasizes their importance in basic neuronal transmission.

© Copyright Pub Med


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