CBG In Phoenix Cannabigerol - azWHOLEistic Phoenix CBD Dispensary

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CBG – Cannabigerol

CBG is a single molecule – like CBD which many people are already aware of… found in the Cannabis and the HEMP plant. All our products are extracted from Hemp per the Hemp Farm Bill. This molecule has influence over a vast array of receptors throughout the body and brain through the Endo-Cannabinoid System.

As with all cannabinoids…these receptors modulate many physiological conditions like pain, gastrointestinal conditions including IBS. Cannabinoid receptors are also highly concentrated in the structures of the eye. CBG has shown effectiveness at reducing intraocular eye pressure associated with conditions like Glaucoma and Retinopathy.

It’s natural anti-inflammatory benefits ( TRPV-1 receptor ) combined with influence to the serotonin receptor – (5-HT1a receptor) makes CBG appropriate for anxiety and the reduction of cortisol in the brain.

To summarize CBG works as well as CBD, perhaps better on pain, but with the added benefits of Gastro-intestinal and vision conditions.

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CBG and The Endocannabinoid System

The human body’s built-in endocannabinoid system (eCS) works to keep the body in its balanced state of homeostasis. While there are specific details about how cannabinoids work, in general the endocannabinoid system performs different functions specific to each area of the body. For example, at an injury site, the eCS can help regulate immune cells to limit inflammation. New studies indicate CBG may help with pain as much or more than CBD.

Promising Uses For CBG

CBG has been found to act on very specific physiological systems and results for medicinal use are promising:

Endocannabinoid receptors are prevalent in eye structures, and interestingly, CBG is thought to be effective in helping glaucoma because it reduces intraocular pressure.
In animal experiments involving mice, CBG was found to be effective in decreasing the inflammation characteristic of inflammatory bowel disease.
In a recent 2015 study, CBG was shown to protect neurons in mice with Huntington’s disease, which is characterized by nerve cell degeneration in the brain.
European research shows evidence that CBG is an effective antibacterial agent, particularly against methicillin-resistant Staphylococcus aureus (MRSA) microbial strains resistant to several classes of drugs.
In a very recent 2017 study, researchers showed that a form of CBG purified to remove delta-9 THC was a very effective appetite stimulant in rats. This may lead to a novel non-psychotropic therapeutic option for cachexia, the muscle wasting and severe weight loss seen in late stage cancer and other diseases.

Mother Cannabinoid

CBG has been referred to as the mother of all cannabinoids. Early in the cannabis flowering cycle, cannabigerolic acid (CBGA) is converted by enzymes to cannabinoids including THC, CBD, CBG, cannabinol (CBN), and cannabichromene (CBC). Because CBGA is quickly converted to THC or CBD as the plant matures, only small amounts of CBG are found in the Cannabis sativa plant. The low concentration of CBG in the plant has made studying the compound challenging. However, in hemp and species with low THC concentration, the concentration of CBG can be much higher. Furthermore, genetic modification has resulted in some strains being developed that are almost all CBG and CBGA.

Pharmacology

CBG is a relatively weak partial agonist of the cannabinoid receptors CB1 and CB2, with its effects at CB2 thought to play a role in inhibiting the intoxicating effects of THC. CBG also increases the body’s endogenous anandamide, which is involved in pain, depression, appetite, memory, and fertility.

CBG has been found to interact with a number of receptors implicated in pain, inflammation, and heat sensitization including transient receptor potential (TRP) channels. CBG stimulates TRPV1, TRPV2, TRPV3, TRPV4, and TRPA1 receptors and antagonizes TRPM8 receptors.

CBG Research Continues

Scientists are excited about these initial CBG results and are promoting future research with CBG alone or CBG in combination with other cannabinoids and therapies for the treatment of multiple maladies. Because it is non-psychotropic, CBG has a promising wide range of potential applications not only for the problems mentioned above, but also as an analgesic, therapy for psoriasis, and as an antidepressant.