Tag Archives: Morphine Addiction

Mice were rendered morphine-dependent by the subcutaneous implantation of a pellet containing 75 mg of morphine base; 72 h after the implantation, the animals were injected intraperitoneally either with vehicle or with various doses of Δ9-tetrahydrocannabinol, Δ8-tetrahydrocannabinol, cannabidiol, cannabinol, or 11-hydroxy-Δ8-tetrahydrocannabinol. Thirty minutes after injection of the cannabinoids, the antagonist, naloxone HCl, was administered to […]