|Working with mouse models, they found that gut bacteria can regulate the liver’s immune response to both primary and metastatic tumors. Although previous studies had already revealed that the huge colonies of bacteria that live in the gut can influence how the immune system deals with cancer, it was not clear how this happened in the liver.|
The new study now reveals that a particular species of the Clostridium genus that is present in the gut can block antitumor activity in the liver by altering bile acids.
A report on the research — which was led by the National Cancer Institute (NCI) in the National Institutes of Health (NIH) at Bethesda, MD — can be found in the journal Science.
Not only do they give new insights into the development of cancer in the liver, but the findings also raise the question of whether reducing the particular microbes might help the immune system to fight the cancer.